Pharmaceutical formulations for the treatment of gastrointestinal disorders

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United States of America Patent

PATENT NO 12098149
APP PUB NO 20230373990A1
SERIAL NO

18363600

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

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Patent Owner(s)

Patent OwnerAddress
RENEXXION LLC325 SHARON PARK DRIVE #303 MENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Druzgala, Pascal Jean Santa Rosa, US 6 14
Tien, Jien Heh Evanston, US 4 8

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