Determining a bulk concentration of a target in a sample using a digital assay with compartments having nonuniform volumes

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United States of America Patent

PATENT NO 12097499
APP PUB NO 20230149932A1
SERIAL NO

18151011

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.

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Patent Owner(s)

Patent OwnerAddress
TOKITAE LLC14360 SE EASTGATE WAY BELLEVUE WA 98007

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Byrnes, Samantha A Seattle, US 5 0
Huynh, Toan Seattle, US 17 300
Nichols, Kevin Paul Flood Issaquah, US 21 222
Weigl, Bernhard Hans Seattle, US 16 87

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