Bispecific antibody

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United States of America Patent

PATENT NO 12091461
APP PUB NO 20210332134A1
SERIAL NO

17366878

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A bispecific antibody which is capable of specifically binding to PD-1 and CD3 is disclosed. The bispecific antibody is suitable for preventing, suppressing symptom progression or recurrence of, and/or treating autoimmune diseases. Also disclosed is a formulation which can reduce occurrence of adverse infusion reactions or adverse reaction called cytokine release syndrome. The bispecific antibody has the feature to allow interaction between PD-1 and PD-L1 as its ligand, contributes enhancement or duration of its effects.

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Patent Owner(s)

Patent OwnerAddress
ONO PHARMACEUTICAL CO LTD1-5 DOSHOMACHI 2-CHOME CHUO-KU OSAKA-SHI OSAKA 5418526 ?5418526

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Klooster, Rinse Utrecht, NL 15 14
Kruif, Cornelis Adriaan de Utrecht, NL 3 3
Loo, Pieter Fokko van Utrecht, NL 3 3
Shibayama, Shiro Ibaraki, JP 84 3261
Shimbo, Takuya Ibaraki, JP 6 17
Tezuka, Tomoya Ibaraki, JP 7 5
Throsby, Mark Utrecht, NL 72 1481

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