Long acting glucagon like polypeptide-1 (GLP-1) receptor agonists and methods of use

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United States of America Patent

PATENT NO 12084485
APP PUB NO 20230063420A1
SERIAL NO

17553381

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Abstract

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This invention relates to isolated polypeptides that are long acting analogs of human GLP-1. The disclosed GLP-1 receptor agonist polypeptides have beneficial physicochemical properties relative to endogenous GLP-1 and known synthetic GLP-1 receptor agonist polypeptides, such as longer (i.e., “long-acting”) elimination half-lives (t1/2), and improved solubility and thermal stability. This invention also relates to methods of using presently disclosed GLP-1 receptor agonist polypeptides in a variety of therapeutic indications, as well as methods of producing the same. The disclosed GLP-1 receptor agonist polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as type 2 diabetes, treating obesity, and providing weight loss, and in methods of treating nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH).

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Patent Owner(s)

Patent OwnerAddress
INTARCIA (ASSIGNMENT FOR THE BENEFIT OF CREDITORS) LLC3945 FREEDOM CIRCLE SUITE #560 SANTA CLARA CA 95054

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blackwell, William Boston, US 15 50
Paulik, Mark Boston, US 15 465
Srivastava, Ved P Boston, US 14 39

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