Methods for site specific conjugation of proteins containing glycosylated Fc domains
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United States of America Patent
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Sep 10, 2024
Grant Date -
Nov 25, 2021
app pub date -
May 19, 2021
filing date -
May 20, 2020
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Abstract
Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.
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