Hierarchical silica lamella for magnetic nucleic acid extractions

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United States of America

PATENT NO 12083534
SERIAL NO

17518183

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Abstract

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Disclosed herein is a novel method to fabricate magnetic silica nanomembranes using thin polymer cores based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the magnetic silica nanomembranes can be used for solid phase extraction of nucleic acids. The magnetic silica nanomembranes are suitable for nucleic acid purification and isolation and demonstrated better performance than commercial particles in terms of nucleic acid recovery yield and integrity. In addition, the magnetic silica nanomembranes may have high nucleic acid capacity due to significantly enlarged specific surface area of silica. Methods of use and devices comprising the magnetic silica nanomembranes are also provided herein.

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Patent Owner(s)

Patent OwnerAddress
PACIFIC BIOSCIENCES OF CALIFORNIA INCMENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burke, Jeffrey Michael Baltimore, US 5 0
Liu, Kelvin Jeng-Fang Baltimore, US 7 1

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