Compounds for targeting mutant huntingtin protein and uses thereof

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United States of America Patent

PATENT NO 12083108
APP PUB NO 20220409600A1
SERIAL NO

17752683

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Abstract

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The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

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Patent Owner(s)

  • CHDI FOUNDATION INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bard, Jonathan New York, US 18 139
Coe, Samuel Northampton, GB 8 61
Dominguez, Celia Los Angeles, US 115 1411
Lee, Matthew R San Diego, US 7 94
Liu, Longbin Los Angeles, US 74 1475
Prime, Michael Edward Swindon, GB 12 90

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