Method for biocatalytic protein-oligonucleotide conjugation

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United States of America Patent

PATENT NO 12077795
APP PUB NO 20200377920A1
SERIAL NO

16989843

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Abstract

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A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferase catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferase catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferase catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand.

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Patent Owner(s)

Patent OwnerAddress
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKP O BOX 6000 BINGHANTON NY 13902-6000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Callahan, Brian Binghamton, US 8 681
Owen, Timothy Huntington, US 12 876

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