Suspension system for adeno associated virus production

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United States of America Patent

PATENT NO 12077784
APP PUB NO 20230193214A1
SERIAL NO

18168396

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Abstract

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The instant technology relates to a production system to produce AAV vectors in a serum free suspension platform and at high titers. This technology uses reagents comprising media, cells, transfection reagent, AAV enhancer, and a lysis buffer, each of which is designed to provide maximal AAV production from suspension culture of mammalian cells, e.g. HEK293 cells. With this new system we are able to deliver up to about 2×1011 viral genomes per milliliter (vg/mL) of unconcentrated AAV vectors.

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Patent Owner(s)

Patent OwnerAddress
LIFE TECHNOLOGIES CORPORATION5791 VAN ALLEN WAY CARLSBAD CA 92008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
de, Mollerat du Jeu Xavier Encinitas, US 24 188
Lin, Chao Yan Germantown, US 1 0
Liu, Jian Carlsbad, US 667 5710
Yu, Xin Zhangiagang, CN 196 1185
Zmuda, Jonathan Frederick, US 11 14

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