Process for the preparation of 3α-hydroxy-5α-pregnan-20-one (brexanolone)

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United States of America

PATENT NO 12077559
SERIAL NO

17282772

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Abstract

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The present invention relates to a new process for the synthesis of 3α-hydroxy-5α-pregnan-20-one, commonly known as brexanolone, wherein the corresponding cyclic 20-ketal or cyclic 20-thioketal compound of formula (IV) is deprotected with the use or iodine in an organic solvent: (I).

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INDUSTRIALE CHIMICA S R L20145 MILANO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borelli, Tea Como, IT 1 0
Delfrate, Claudio Rho, IT 4 0
Lenna, Roberto S. Giorgio su Legnano, IT 29 20
Rigamonti, Davide Erba, IT 3 0

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