Nucleic acids for inhibiting expression of TMPRSS6 and iron chelators
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United States of America Patent
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Sep 3, 2024
Grant Date -
Oct 20, 2022
app pub date -
Jul 26, 2019
filing date -
Jul 26, 2018
priority date (Note) -
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Abstract
The present invention relates to products and compositions and their uses. In particular the invention relates to nucleic acid products that interfere with the TMPRSS6 gene expression or inhibits its expression in combination with one or more iron chelators and possibly other active agents, as well as therapeutic uses such as for the treatment of hemochromatosis, porphyria and blood disorders such as beta-thalassemia, sickle cell disease and transfusional iron overload or myelodysplastic syndrome, and infections and non-relapse related mortality associated with bone marrow transplantation.
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