Method of osteogenic differentiation in microfluidic tissue culture systems

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United States of America Patent

PATENT NO 12070746
APP PUB NO 20180305668A1
SERIAL NO

15958142

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Abstract

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Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.

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Patent Owner(s)

Patent OwnerAddress
CEDARS-SINAI MEDICAL CENTER8700 BEVERLY BLVD LOS ANGELES CA 90048
EMULATE INC27 DRYDOCK BOSTON MA 02210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gazit, Dan Los Angeles, US 42 523
Gazit, Zulma Los Angeles, US 21 357
Hamilton, Geraldine Boston, US 38 152
Hinojosa, Christopher David Cambridge, US 74 384
Pelled, Gadi Los Angeles, US 30 403
Sheyn, Dmitriy Los Angeles, US 7 36
Wen, Norman West Roxbury, US 48 248

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