Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth
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United States of America Patent
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Aug 20, 2024
Grant Date -
Jul 1, 2021
app pub date -
Jan 7, 2021
filing date -
Feb 24, 2017
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Abstract
A method includes simultaneously measuring electrophysiological responses and contractility responses of a plurality of cells forming a tissue culture using a system comprising a sensor array configured to simultaneously measure the electrophysiological responses and the contractility responses of the plurality of cells forming the tissue culture. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.
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