Methods of measuring extracellular vesicles and nanoparticles in complex matrices by light scattering

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United States of America Patent

PATENT NO 12066382
APP PUB NO 20210262931A1
SERIAL NO

17254221

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Abstract

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Described herein are novel rapid and reliable methods of detection of extracellular vesicles and quantifying extracellular vesicle concentrations and absolute number from various sources, including raw cell harvest. The methods described herein comprise detection of light scattering of extracellular vesicles in biological samples. Extracellular vesicles analyzed by the methods of this application have a stereotypical elution profile distinct from known contaminants. The methods described herein are a significant improvement over the state of the art and fulfills an unmet need in the field of extracellular vesicle manufacturing and quality control.

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Patent Owner(s)

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LONZA SALES AGMÜNCHENSTEINERSTRASSE 38 BASEL 4052

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Delai Cambridge, US 23 596
Choi, Young Jun Cambridge, US 42 174
Houde, Damian J Plymouth, US 11 29
Williams, Douglas E Boston, US 31 246

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