Fluorescent proanthocyanidins

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United States of America Patent

PATENT NO 12065449
APP PUB NO 20240059713A1
SERIAL NO

18547958

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Abstract

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Proanthocyanidin-cinnamaldehydes pyrylium products (FP) were synthesized by the condensation reaction of proanthocyanidins (PAC) with various cinnamaldehydes. Synthesized FP exhibited fluorescence at higher excitation and emission wavelengths than PAC. FP were evaluated for their ability to agglutinate extra-intestinal pathogenic Escherichia coli (ExPEC). Results showed that FP were significantly more bioactive (p-value<0.05) for agglutinating ExPEC compared to PAC. Scanning electron microscopy indicates that FP interacts with ExPEC surface structures and suggests that FP have higher affinity with the fimbriae-like structures on the surface of ExPEC in comparison to PAC. In addition, fluorescent microscopy performed on in vitro and in vivo agglutination assays show that FP entrap ExPEC in a web-like network, thus demonstrating agglutination of ExPEC. Fluorescent proanthocyanidins offer a new approach to visualize bacterial infections and to treat such infections.

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Patent Owner(s)

Patent OwnerAddress
SYNESIS LLC404 DALY AVENUE WISCONSIN RAPIDS WI 54494

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alfaro-Viquez, Emilia Wisconsin Rapids, US 3 3
Esquivel-Alvarado, Daniel Alfredo Wisconsin Rapids, US 1 0
Krueger, Christian G Cambridge, US 3 1
Reed, Jess D Verona, US 4 5

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