Phytonadione compositions and related methods
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United States of America Patent
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Aug 20, 2024
Grant Date -
Nov 25, 2021
app pub date -
Aug 3, 2021
filing date -
Feb 27, 2015
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Abstract
Stable Phytonadione compositions for parenteral administration are provided which comprise (E) isomer of phytonadione at or greater than 97% w/w as the active ingredient, and is substantially free of (Z) isomer. Said compositions are stable, sterile, and particulate-free. Further, said compositions reduce or avoid allergic reactions to benzyl alcohol and polysorbate. In some aspects, the compositions are free or substantially free of benzyl alcohol and/or reduced amounts of polysorbate. Methods of manufacture and methods of administration also provided.
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