High fidelity restriction endonucleases

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United States of America Patent

PATENT NO 12060587
APP PUB NO 20210238566A1
SERIAL NO

17226693

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Abstract

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Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) In a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

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Patent Owner(s)

Patent OwnerAddress
NEW ENGLAND BIOLABS INC240 COUNTY ROAD IPSWICH MA 01938

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chan, Siu-hong Ipswich, US 35 8
Guan, Shengxi Stoneham, US 46 253
Huang, Yishu Shanghai, CN 13 1
Lai, Xuhui Shanghai, CN 11 0
Li, Xianghui Shanghai, CN 11 0
Quimby, Aine Newton, US 48 105
Sun, Dapeng Arlington, US 53 43
Xu, Shuang-Yong Lexington, US 77 180
Zhang, Chunhua Ipswich, US 34 65
Zhu, Zhenyu Beverly, US 133 394

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