Cleavable surfactants

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United States of America Patent

PATENT NO 12060538
APP PUB NO 20230183603A1
SERIAL NO

18045281

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Abstract

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The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

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Patent Owner(s)

Patent OwnerAddress
PROMEGA CORPORATION2800 WOODS HOLLOW ROAD MADISON WI 53711-5399

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hitko, Carolyn Woodroofe Grover Beach, US 7 18
Klaubert, Dieter Arroyo Grande, US 59 1007
Saveliev, Sergei Madison, US 5 7
Simpson, Daniel Middleton, US 11 54
Uyeda, Harry Tetsuo Los Osos, US 18 55
Wood, Keith V Mount Horeb, US 149 3646

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