IL-15/IL-15Ralpha based conjugates purification method
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United States of America Patent
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Aug 13, 2024
Grant Date -
Jan 14, 2021
app pub date -
Sep 18, 2020
filing date -
Mar 3, 2014
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Abstract
The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Rα or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method.
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