Detection of tumor-derived DNA in cerebrospinal fluid

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United States of America Patent

PATENT NO 12054781
APP PUB NO 20190002987A1
SERIAL NO

15744299

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Abstract

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As cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we assessed the cerebrospinal fluid (CSF) that bathes the CNS for tumor DNA, here termed CSF-tDNA. The results suggest that CSF-tDNA could be useful for the management of patients with primary tumors of the brain or spinal cord.

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Patent Owner(s)

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THE JOHNS HOPKINS UNIVERSITY3400 NORTH CHARLES STREET BALTIMORE MD 21218

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bettegowda, Chetan Perry Hall, US 16 38
Diaz, Luis Ellicot City, US 72 576
Kinzler, Kenneth W Baltimore, US 296 5437
Papadopoulos, Nickolas Towson, US 104 1312
Vogelstein, Bert Baltimore, US 338 7135
Wang, Yuxuan Baltimore, US 36 398

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