Method of ctDNA library construction and sequencing data analysis for simultaneously detecting multiple common mutations in liver cancer

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United States of America

PATENT NO 12054710
SERIAL NO

17257611

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Abstract

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A method of ctDNA library construction and sequencing data analysis for simultaneously detecting multiple common mutations in liver cancer. The library construction method and sequencing data analysis process have the following advantages: 1. Simultaneous detection of multiple mutation forms in liver cancer without capturing; 2. Suitable for efficient capture of ultra-small target regions; 3. The library may support 10-20 tests; 4. Ligate the DNA barcode to the starting ctDNA molecule during the library construction process, and cooperate with the biological information analysis process to achieve high specific detection of low-frequency mutations in ctDNA; 5. The library is usable for PCR hot spots detection and sequencing by a capture method at the same time, the added DNA barcode may effectively filter out false positive mutations and achieve high-specificity sequencing based on duplex. The disclosure helps with early screening, disease tracking, efficacy evaluation, prognosis prediction and the like of liver cancer.

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Patent Owner(s)

Patent OwnerAddress
CANCER HOSPITAL CHINESE ACADEMY OF MEDICAL SCIENCES17 PANJIAYUAN NANLI CHAOYANG DISTRICT BEIJING 100021 100021
GENETRON HEALTH (BEIJING) CO LTD102206 BUILDING 10 AREA 1 NO 8 SHENGSHENGYUAN ROAD ZHONGGUANCUN LIFE SCIENCE PARK CHANGPING DISTRICT BEIJING BEIJING CITY BEIJING CITY 102206

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Kun Beijing, CN 67 210
Jiao, Yuchen Beijing, CN 11 5
Qu, Chunfeng Beijing, CN 3 0
Song, Qianqian Beijing, CN 13 31
Wang, Pei Beijing, CN 112 748
Wang, Sizhen Beijing, CN 6 0
Wang, Yuting Beijing, CN 47 147
Yan, Hai Beijing, CN 85 1001

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