Anti-hla-A2 antibodies and methods of using the same
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United States of America Patent
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Jul 30, 2024
Grant Date -
Sep 10, 2020
app pub date -
Sep 19, 2018
filing date -
Sep 19, 2017
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Abstract
Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the CAR specifically binds to HLA-A2. Also provided are CARs that include the humanized anti-HLA-A2 antibodies. Modified cells including the antibodies and CARs, as well as methods of using such modified cells are also provided.
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