Anti-VEGF protein compositions and methods for producing the same

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United States of America Patent

PATENT NO 12049489
APP PUB NO 20240067701A1
SERIAL NO

18340707

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Abstract

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The present disclosure pertains to methods for producing aflibercept from a host cell cultured in a chemically defined medium (CDM) including purification of aflibercept, wherein aflibercept following purification includes aflibercept variants that have at least one oxidized amino acid residue selected from the group consisting of tryptophan, histidine and a combination thereof.

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Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591-6707

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Daly, Thomas New City, US 69 533
Li, Ning New Canaan, US 758 4862
Palackal, Nisha White Plains, US 22 57
Pyles, Erica New City, US 32 59
Tustian, Andrew Millwood, US 29 114
Vartak, Ankit Greenwich, US 22 58
Wang, Shunhai Scarsdale, US 83 157

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