Substituted benzopyrazolo[1,5-a][1,4]diazepines as GABA positive allosteric modulators

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United States of America Patent

PATENT NO 12049467
APP PUB NO 20220251090A1
SERIAL NO

17590404

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Abstract

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This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt thereof, or an N-oxide thereof) of formula (I), which are positive allosteric modulators of one or more GABA-A receptors, e.g., which are peripherally restricted, positive allosteric modulators of one or more GABA-A receptors; e.g., which are positive allosteric modulators of one or more GABA-A receptors and which selectively target the peripheral nervous system and organs of the body, and which do not substantially pass through the blood-brain barrier. Said compounds are useful e.g., for the treatment of systemic diseases of the body, e.g., diseases in which modulation of one or more peripherally restricted GABA-A receptors is beneficial (e.g., diseases or disorders which are mediated by GABA-A neuronal activity. This disclosure also features pharmaceutical compositions containing the chemical entities described herein as well as methods of using same for the treatment of systemic diseases of the body.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITY3400 NORTH CHARLES STREET BALTIMORE MD 21218

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barrow, James C Arnold, US 47 267
Buchler, Ingrid Baltimore, US 3 13
Huang, Yifang Lansdale, US 24 81
Pasricha, Pankaj Jay Ellicott City, US 39 2648
Poslusney, Michael Baltimore, US 4 0

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