Methods for detecting and reversing immune therapy resistance

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United States of America Patent

PATENT NO 12048745
APP PUB NO 20190336600A1
SERIAL NO

16400595

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Abstract

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Compositions and methods of their use to detect and treat anti-PD1 therapy resistance are provided herein. Compositions that immunospecifically bind and deplete dysfunctional T cells are provided. The dysfunctional T cells that are depleted include CD38+PD-1+ T cells, CD38+CD8+ T-cells, or both. The dysfunctional T cells can be depleted, for example, by administering an antibody or fusion protein that specifically binds to dysfunctional T cells and promotes their depletion. In one embodiment the antibody is a bispecific antibody that can be specific for CD38 and CD8, or it can be specific for CD38 and PD-1. Also disclosed is a method of detecting and treating anti-PD1 therapy resistance by measuring the amount of CD38+PD1+CD8 T cells in blood or tissue samples obtained from a subject prior to anti-PD1 therapy and administering an anti-CD38/CD8 or anti-CD38/PD-1 depleting/blocking antibody to the subject prior to anti-PD1 therapy.

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Patent Owner(s)

Patent OwnerAddress
AUGUSTA UNIVERSITY RESEARCH INSTITUTE INC1120 15TH STREET CJ-3301 AUGUSTA GA 30912

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gupta, Seema Bethesda, US 4 13
Khleif, Samir N Silver Spring, US 27 83
Verma, Vivek Augusta, US 26 424

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