Substrates and optical systems and methods of use thereof

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United States of America Patent

PATENT NO 12043868
APP PUB NO 20240076733A1
SERIAL NO

18085837

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Abstract

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This invention provides devices for use in various analytical applications including single-molecule analytical reactions. Methods for detecting analytes optically by propagating optical energy by waveguides within a substrate are provided. Analytical devices are provided which have both shallow and deep waveguides in which illumination light is transported through the deep waveguides and coupled into the shallow waveguides. The shallow waveguides provide evanescent field illumination to analytes, such as single-molecule analytes, within nanometer scale wells. Integrated devices including integrated detectors such as CMOS detectors are included.

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Patent Owner(s)

Patent OwnerAddress
PACIFIC BIOSCIENCES OF CALIFORNIA INCMENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bayandorian, Hovig Berkeley, US 12 842
Foquet, Mathieu Newark, US 50 4763
Korlach, Jonas Camas, US 134 10368
Lundquist, Paul San Francisco, US 81 4059
Zhong, Cheng Frank Fremont, US 50 1449

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