Cell capture and expansion
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United States of America Patent
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Jul 23, 2024
Grant Date -
Sep 29, 2022
app pub date -
Mar 23, 2022
filing date -
Mar 23, 2022
priority date (Note) -
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Abstract
Implementations are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In implementations, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other implementations, the cells may be grown in co-culture with other cells, e.g., hMSC's. In implementations, the cells may include CD34+ cells. A coated membrane includes a membrane having a first coating configured to promote cellular adhesion to the membrane and a second coating that includes a soluble protein moiety.
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