10E8 neutralizing antibody variants that bind to the MPER region of HIV-1 GP41 and their use

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United States of America

PATENT NO 12043660
SERIAL NO

17551066

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Abstract

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Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK412 LOW MEMORIAL LIBRARY 535 W 116TH STREET NEW YORK NY 10027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Asokan, Mangaiarkarasi Rockville, US 5 26
Bailer, Robert Adamstown, US 2 0
Bender, Michael Washington, US 381 2123
Carlton, Kevin Gaithersburg, US 3 8
Chuang, Gwo-Yu Rockville, US 23 84
Connors, Mark Bethesda, US 28 135
Cooper, Jonathan Arlington, US 27 390
Georgiev, Ivelin Nashville, US 19 43
Gindin, Tatyana New York, US 2 0
Kueltzo, Lisa Gaithersburg, US 2 0
Kwon, Young Do Kensington, US 65 1270
Kwong, Peter Washington, US 55 200
Louder, Mark Mt. Airy, US 2 0
Mascola, John Rockville, US 51 109
McKee, Krisha Columbia, US 2 0
O'Dell, Sijy Silver Spring, US 2 0
Ofek, Gilad Gaithersburg, US 14 76
Pegu, Amarendra Potomac, US 9 26
Schwartz, Richard Bethesda, US 66 1462
Shapiro, Lawrence New York, US 12 910
Zhang, Baoshan Bethesda, US 35 163

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