Magnetically modulated computational cytometer and methods of use

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United States of America Patent

PATENT NO 12038370
APP PUB NO 20220260481A1
SERIAL NO

17621979

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A computational cytometer operates using magnetically modulated lensless speckle imaging, which introduces oscillatory motion to magnetic bead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three-dimensions (3D). Detection specificity is further enhanced through a deep learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network (P3D CNN), which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic force. This compact, cost-effective and high-throughput computational cytometer can be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET TWELFTH FLOOR OAKLAND CA 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Di, Carlo Dino Los Angeles, US 76 843
Ozcan, Aydogan Los Angeles, US 103 2065
Ray, Aniruddha Los Angeles, US 13 58
Zhang, Yibo Los Angeles, US 69 1498

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