CRISPR effector system based diagnostics

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United States of America Patent

PATENT NO 12037639
APP PUB NO 20190309357A1
SERIAL NO

16285128

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Abstract

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The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

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Patent Owner(s)

Patent OwnerAddress
THE BROAD INSTITUTE INC415 MAIN STREET CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abudayyeh, Omar Cambridge, US 54 344
Collins, James Joseph Cambridge, US 11 250
Gootenberg, Jonathan Cambridge, US 59 955
Lander, Eric S Cambridge, US 79 1197
Zhang, Feng Cambridge, US 1002 28040

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