Enzymatic synthesis of 4′-ethynyl nucleoside analogs
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United States of America Patent
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Jul 16, 2024
Grant Date -
Jul 21, 2022
app pub date -
Jul 2, 2019
filing date -
Jul 9, 2018
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Abstract
The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.
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