Compound having affinity substance to soluble protein, cleavable portion and reactive group, or salt thereof

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United States of America Patent

PATENT NO 12024549
APP PUB NO 20200190165A1
SERIAL NO

16663791

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Abstract

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The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I):

description='In-line Formulae' end='lead'A-L-B-R  (I)description='In-line Formulae' end='tail'

    wherein A is an affinity substance to a soluble protein;L is a cleavable linker which is a divalent group comprising a cleavable portion;B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; andR is a reactive group to the soluble protein; ora salt thereof.

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Patent Owner(s)

  • AJINOMOTO CO. INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujii, Tomohiro Kawasaki, JP 49 279
Ito, Yuji Kagoshima, JP 305 3334
Matsuda, Yutaka Kawasaki, JP 87 1208
Shikida, Natsuki Kawasaki, JP 7 4
Shimbo, Kazutaka Kawasaki, JP 25 102
Yamada, Kei Kawasaki, JP 30 161
Yuji, Reiko Kawasaki, JP 2 2

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