Selective oxidation of 5-methylcytosine by TET-family proteins

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United States of America Patent

PATENT NO 12018320
APP PUB NO 20220348995A1
SERIAL NO

17675502

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Abstract

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The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.

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Patent Owner(s)

  • THE CHILDREN'S MEDICAL CENTER CORPORATION; THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agarwal, Suneet Belmont, US 50 770
Iyer, Aravind Bethesda, US 42 837
Koh, Kian Peng Jamaica Plain, US 39 747
Rao, Anjana La Jolla, US 75 871
Tahiliani, Mamta New York, US 39 747

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