Human amylin analog polypeptides and methods of use

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United States of America Patent

PATENT NO 12018059
APP PUB NO 20200115430A1
SERIAL NO

16598915

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Abstract

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This invention relates to isolated polypeptides that are analogs of human amylin. The disclosed amylin analog polypeptides have beneficial physicochemical properties relative to endogenous amylin, such as longer elimination half-lives (t1/2) and improved solubility and thermal stability. This invention also relates to methods of using presently disclosed amylin analog polypeptides in a variety of therapeutic indications, as well as methods of producing the same. The disclosed amylin analog polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as types 1 and 2 diabetes, and providing weight loss.

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Patent Owner(s)

  • I2O THERAPEUTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blackwell, William Boston, US 15 50
Srivastava, Ved P Boston, US 14 39
Way, James M Boston, US 6 3

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