Method for detecting flavivirus-specific antibodies utilizing flaviviral NS1 polypeptides comprising the wing domain

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United States of America Patent

PATENT NO 12018053
APP PUB NO 20220220158A1
SERIAL NO

17705704

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Abstract

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The disclosure relates to a polypeptide suitable for detecting antibodies against a flavivirus in an isolated biological sample having a flavivirus NS1 wing domain specific amino acid sequence, wherein no amino acid sequences from the NS1 β-ladder domain of said flavivirus are present in the polypeptide. In an embodiment, the flavivirus is selected from Zika virus (ZIKV), West-Nile virus (WNV), Dengue virus types 1-4 (DENV1-4), tick-borne encephalitis virus (TBEV), yellow fever virus (YFV) and Japanese encephalitis virus (JEV). Also disclosed is a method for producing said flaviviral NS1 wing domain specific polypeptides, a method for detecting antibodies specific for a first flavivirus species, the use of said flaviviral NS1 wing domain specific polypeptides for detecting antibodies as well as a reagent kit for detecting said flavivirus antibodies that has a flavivirus NS1 wing domain polypeptide.

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Patent Owner(s)

Patent OwnerAddress
ROCHE DIAGNOSTICS OPERATIONS INC9115 HAGUE ROAD INDIANAPOLIS IN 46250

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benz, Juliane Weilheim, DE 6 1
Faatz, Elke Huglfing, DE 34 162
Gloeck, Mario Geretsried, DE 3 2
Luebcke, Silke Munich, DE 3 2
Muench, Peter Penzberg, DE 18 56
Riedel, Alexander Munich, DE 7 2
Scholz, Christian Penzberg, DE 75 385
Tabares, Gloria Munich, DE 8 2

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