Processes for immobilising biological entities

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 12016978
APP PUB NO 20220378985A1
SERIAL NO

17871189

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Abstract

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According to the invention there is provided inter alia a process for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulant entity, comprising the steps of:

    i) treating a surface of the solid object with a cationic polymer;ii) treating the surface with an anionic polymer;iii) optionally repeating steps i) and ii) one or more times;iv) treating the surface with a cationic polymer; andv) treating the outermost layer of cationic polymer with an anticoagulant entity, thereby to covalently attach the anticoagulant entity to the outermost layer of cationic polymer; wherein, the anionic polymer is characterized by having (a) a total molecular weight of 650 kDa-10,000 kDa; and (b) a solution charge density of >4 μeq/g; and wherein, step ii) is carried out at a salt concentration of 0.25 M-5.0 M.

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Patent Owner(s)

Patent OwnerAddress
CARMEDA AB194 61 UPPLANDS VÄSBY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Antoni, Per Upplands Väsby, SE 16 85
Eriksson, Malin Upplands Väsby, SE 9 11
Gällhagen, Anna Upplands Väsby, SE 5 3
Göransson, Helena Upplands Väsby, SE 5 3
Koch, Eva Upplands Väsby, SE 18 41
Nyström, Daniel Upplands Väsby, SE 10 26
Porsch-Grahm, Christian Upplands Väsby, SE 5 3

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