Anticancer compositions and methods for making and using them

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United States of America Patent

PATENT NO 12016877
APP PUB NO 20230405038A1
SERIAL NO

17895007

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for treating or ameliorating a cancer by inhibiting expression or activity of Mouse Double Minute 2 homolog (MDM2), an APOBEC3G (A3G) protein, message (mRNA) or gene, and/or an ADAR1p150 protein, message (mRNA) or gene, e.g., by increasing the presence of in a cell or adding to a cell a molecule inhibitory to MDM2, APOBEC3G and/or ADAR1p150 expression, such as an miRNA that binds to MDM2, APOBEC3G and/or ADAR1p150 transcripts, or any molecule that can inhibit or destabilize the transcripts, resulting in decreased MDM2, APOBEC3G and/or ADAR1p150 expression, to treat a cancer such as leukemia, e.g., by inhibiting the propagation of a cancer cell, a leukemia cell, a leukemia stem cell (LSC) or a pre-leukemia cell stem cell (pre-LSC).

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Patent Owner(s)

Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET TWELFTH FLOOR OAKLAND CA 94607-5200 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Diep, Raymond San Diego, US 3 0
Isquith, Jane San Diego, US 3 0
Jamieson, Catriona San Diego, US 13 31
Jiang, Qingfei San Diego, US 7 3
Pham, Jessica San Diego, US 5 0

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