Electroporation with active compensation

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12006507
SERIAL NO

16935987

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Abstract

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An apparatus for electroporating cells with a cargo includes electrodes defining a path for a fluid including the cells and the cargo to flow, a power source coupled across the electrodes, and a control circuit. In some examples, the control circuit is configured to detect a decrease in an induced current due to an increase in a resistance between the electrodes, and control the power source to increase the induced current to maintain an electric field between the electrodes. A future value of the resistance between the electrodes may be predicted based on previous values of the resistance. In other examples, the control circuit is configured to detect parameters of the fluid flowing between the electrodes, and control the power source to generate or stop generating electrical pulses in response to detecting the parameters. Other example apparatuses, and methods of electroporating cells with a cargo is also disclosed.

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Patent Owner(s)

Patent OwnerAddress
NANTCELL INC9920 JEFFERSON BOULEVARD CULVER CITY CA 90232

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Chih-Wei Los Angeles, US 386 1345
Mehrabi, Artin Burbank, US 6 3
Van, Lew Jon Thomas Los Angeles, US 7 3

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