Engineered ketoreductase polypeptides and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11999976
APP PUB NO 20210371829A1
SERIAL NO

17290916

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Abstract

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Provided are amino acid sequences of ketoreductase polypeptides that are useful for asymmetrically synthesizing chiral alcohol compounds, its preparation process as well as reaction process under industrial-relevant conditions. Also provided are polynucleotide sequences encoding engineered ketoreductase polypeptides, engineered host cells capable of expressing engineered ketoreductase polypeptides, and methods of producing chiral alcohol compounds using engineered ketoreductase polypeptides. Compared to other enzymes, the engineered ketoreductase polypeptides provided by the invention have better catalytic activity and thermal stability, allowing purification of the enzyme solution by heat treatment, which is advantageous for the production of enzymes and the industrial application of enzymatic reactions. The use of the engineered polypeptides of the present invention greatly simplifies the production process of chiral alcohol compounds, reduces the cost of production and the impact on the environment, and has good industrial application prospects.

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Patent Owner(s)

Patent OwnerAddress
ENZYMASTER (NINGBO) BIO-ENGINEERING CO LTDROOM 333 (6-21) - (6-27) NORTH SECTION OF CENTURY AVENUE YINZHOU DISTRICT NINGBO CITY ZHEJIANG PROVINCE 315000 NINGBO CITY ZHEJIANG PROVINCE 315000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bocola, Marco Ningbo, CN 10 2
Bong, Yong Koy Ningbo, CN 30 53
Cai, Baoqin Ningbo, CN 9 0
Chen, Haibin Ningbo, CN 96 1781
Hong, Ruimei Ningbo, CN 2 0
Shang, Chuanyang Ningbo, CN 2 0
Shi, Shumin Ningbo, CN 6 0
Sun, Lei Ningbo, CN 350 2682

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