Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof

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United States of America Patent

PATENT NO 11993606
APP PUB NO 20230399333A1
SERIAL NO

18453085

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Abstract

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The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

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ABBVIE INC1 NORTH WAUKEGAN ROAD NORTH CHICAGO IL 60064

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Camp, Heidi S Winnetka, US 17 127
Klünder, Ben Ludwigshafen, DE 46 718
Mohamed, Mohamed-Eslam F Gurnee, US 53 876
Othman, Ahmed A Libertyville, US 52 899
Padley, Robert J Highland Park, US 27 211
Pangan, Aileen L La Grange, US 25 386
Song, In-Ho Vernon Hills, US 25 95
Voss, Jeffrey W Hudson, US 40 1081

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