7β-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid

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United States of America Patent

PATENT NO 11981935
APP PUB NO 20210139862A1
SERIAL NO

17150243

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Abstract

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In various aspects and embodiments, the invention provides a nucleic acid molecule comprising a nucleotide sequence encoding a 7β-hydroxysteroid dehydrogenase (7β-HSDH) mutant that catalyzes at least the stereospecific enzymatic reduction of a 7-ketosteroid to the corresponding 7-hydroxysteroid, wherein the mutant has, compared to the wildtype 7β-HSDH of SEQ ID NO:2, a decreased substrate inhibition and/or an altered cofactor usage, and the mutant has, in comparison with the wildtype 7β-HSDH of SEQ ID NO:2, 1 to 15 amino acid additions, substitutions, deletions and/or inversions in the sequence motif VMVGRRE corresponding to positions 36 to 42 of SEQ ID NO:2.

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PHARMAZELL GMBH83064 RAUBLING

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aigner, Arno Tuntenhausen, DE 11 28
Bakonyi, Daniel Cologne, DE 10 6
Braun, Michael Bad Mergentheim-Edelfingen, DE 129 2918
Bresch, Sven Munich, DE 4 6
Hummel, Werner Titz, DE 43 756
Kantzow, Christina Munich, DE 4 6
Sun, Boqiao Munich, DE 5 6
Weuster-Botz, Dirk Munich, DE 16 92

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