System, device and method for production of bioproduct including high density cell respirator (HDCR) for intensified production of adeno-associated viruses (AAV) and cell-based production

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United States of America Patent

PATENT NO 11981885
APP PUB NO 20210147779A1
SERIAL NO

17098259

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Abstract

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A cell cultivation apparatus for cultivating microorganisms and growing cells at high density is provided. The apparatus includes a membrane comprising multiple surface features on a first side of the membrane for cell placement. The surface features comprising one or more compartments within which a cell can be located. The membrane includes a material that is at least partially permeable to gas. A second side of the membrane defines a gas region. The second side of the membrane is separated from the first side of the membrane by the membrane. The apparatus further includes a media region for receiving media. The compartments are configured to at least partially reduce media flow shear forces on one or more cells in the compartments. The surface features may be ridges, protrusions, fins, wells, and/or posts.

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Patent Owner(s)

Patent OwnerAddress
CITY OF HOPE1500 EAST DUARTE ROAD DUARTE CA 91010

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chatterjee, Saswati Altadena, US 29 805
Cook, Colin Andrew Pasadena, US 6 2
Fong, Yuman La Canada, US 35 163
Tai, Yu-Chong Pasadena, US 251 6248

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