Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11968974
APP PUB NO 20190141985A1
SERIAL NO

16244283

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Abstract

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Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK412 LOW MEMORIAL LIBRARY 535 WEST 116TH STREET NEW YORK NY 10027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bacchetta, Matthew Tenafly, US 8 3
Chicotka, Scott New York, US 2 0
Fung, Kenmond New York, US 2 0
Guenthart, Brandon New York, US 3 1
O'Neill, John New York, US 44 365
Vunjak-Novakovic, Gordana New York, US 59 1343

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