Multispecific binding proteins with mutant fab domains

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United States of America Patent

PATENT NO 11965030
APP PUB NO 20200262926A1
SERIAL NO

16725228

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Abstract

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Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

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  • SANOFI - AVENTIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amaral, Marta Frankfurt am Main, DE 2 1
Beil, Christian Frankfurt am Main, DE 29 255
Focken, Ingo Frankfurt am Main, DE 12 49
Hessler, Gerhard Frankfurt am Main, DE 35 450
Hoelper, Soraya Frankfurt am Main, DE 4 3
Jung, Jennifer Frankfurt am Main, DE 6 39
Lange, Christian Frankfurt am Main, DE 81 531
Leuschner, Wulf-Dirk Frankfurt am Main, DE 6 9
Rao, Ercole Frankfurt am Main, DE 59 535
Tiwari, Garima Frankfurt am Main, DE 1 1
Weil, Sandra Frankfurt am Main, DE 6 5

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