Compositions and methods for the depletion of CD117+ cells

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United States of America Patent

PATENT NO 11958908
APP PUB NO 20210206872A1
SERIAL NO

17103866

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Abstract

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The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

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Patent Owner(s)

Patent OwnerAddress
CRISPR THERAPEUTICS AGBAARERSTRASSE 14 ZUG 6300

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boitano, Anthony Newton, US 50 72
Cooke, Michael Brookline, US 59 261
Glanville, Jacob South San Francisco, US 27 171
McDonough, Sean Littleton, US 12 20
Palchaudhuri, Rahul Somerville, US 36 102
Panwar, Rajiv Acton, US 15 27
Pearse, Bradley R Watertown, US 18 41

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