Methods directed to crystalline biomolecules

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United States of America Patent

PATENT NO 11958882
APP PUB NO 20200157141A1
SERIAL NO

16494165

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

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Patent Owner(s)

  • AMGEN INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burt, Neill Denver, US 5 1
Caporini, Marc A Cambridge, US 4 0
Christian, Twinkle R Thousand Oaks, US 13 20
Kelly, Ron C Thousand Oaks, US 17 74
Nicholson, Laura Boulder, US 2 0
Sharnez, Rizwan Mead, US 7 181
Trieu, William Agoura Hills, US 3 7

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