Optimization method for capturing proteins by multi-column continuous chromatography (MCC)

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United States of America Patent

PATENT NO 11958881
APP PUB NO 20230203092A1
SERIAL NO

18117479

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An optimization method for capturing proteins by multi-column continuous chromatography (MCC), including the following steps: step 1, under the conditions of a set loading protein concentration and an arbitrary load residence time, performing a single time of protein breakthrough experiment to obtain a protein breakthrough curve; step 2, under a set breakthrough percentage for a target protein, integrating the breakthrough curve to obtain a single-column loading capacity and establishing a linear relationship between the interconnected load time and the load residence time; step 3, solving for the optimal number of operating columns for capturing proteins by MCC based on step 2; step 4, solving for the optimal load residence time for capturing proteins by MCC based on step 2, step 3; and step 5, solving for the maximum productivity of capturing proteins by MCC based on step 4.

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Patent OwnerAddress
ZHEJIANG UNIVERSITY311121 ZHEJIANG UNIVERSITY NO 866 YUHANGTANG ROAD XIHU DISTRICT HANGZHOU ZHEJIANG PROVINCE (NINGBO NO 6 INSTITUTE OF BINJIANG RESEARCH INSTITUTE ZHEJIANG UNIVERSITY) HANGZHOU CITY ZHEJIANG PROVINCE 311121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lin, Dongqiang Hangzhou, CN 2 0
Shi, Ce Hangzhou, CN 30 21
Yao, Shanjing Hangzhou, CN 2 0

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