HNQO1-activatable fluorescent probe for imaging cancer cells in-vitro and in-vivo

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United States of America Patent

PATENT NO 11957766
APP PUB NO 20210154330A1
SERIAL NO

16950107

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Abstract

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The present invention includes a probe, an assay, a method of detecting, a human NAD(P)H quinone oxidoreductase-1 (hNQO1) enzyme activity with a fluorescent probe comprising a quinone propionic acid (QPA) conjugated to dicyanoisophorone (DCP), wherein the hNQO1 reduces the probe to releases a fluorescent DCP, and a method of making the same.

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Patent Owner(s)

Patent OwnerAddress
TEXAS TECH UNIVERSITY SYSTEMOFFICE OF RESEARCH COMMERCIALIZATION P O BOX 42007 LUBBOCK TX 79409-2007

International Classification(s)

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  • 2020 Application Filing Year
  • A61K Class
  • 21530 Applications Filed
  • 7999 Patents Issued To-Date
  • 37.16 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Punganuru, Surendra R Amarillo, US 1 0
Srivenugopal, Kalkunte S Amarillo, US 3 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges26596611201 - 1011 - 200200040006000800010000120001400016000180002000022000240002600028000

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