Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography

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United States of America Patent

PATENT NO 11945839
APP PUB NO 20200369719A1
SERIAL NO

16955776

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Abstract

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The present invention relates to methods for separating multispecific CrossMab antibodies from light chain mispaired variants thereof in a solution comprising CrossMab bispecific antibodies and mispaired antibody variants thereof by hydrophobic interaction chromatography.

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Patent Owner(s)

Patent OwnerAddress
HOFFMANN-LA ROCHE INC150 CLOVE ROAD OVERLOOK AT GREAT NOTCH SUITE 8 LITTLE FALLS NJ 07424

International Classification(s)

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  • 2018 Application Filing Year
  • C07K Class
  • 7216 Applications Filed
  • 4039 Patents Issued To-Date
  • 55.98 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hertenberger, Hubert Weilheim, DE 8 19
Rueger, Petra Penzberg, DE 39 171
Von, Hirschheydt Thomas Penzberg, DE 17 20
Weydanz, Birgit Penzberg, DE 4 3

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