Compositions and methods for analyzing modified nucleotides

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United States of America Patent

PATENT NO 11939628
APP PUB NO 20210207200A1
SERIAL NO

17181351

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Abstract

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Methods and compositions are provided for identifying any of the presence, location and phasing of methylated and/or hydroxymethylated cytosines in nucleic acids including long stretches of DNA. In some embodiments, the method may comprise reacting a first portion (aliquot) of a nucleic acid sample with a dioxygenase and optionally a glucosyltransferase in a reaction mixture containing the nucleic acid followed by a reaction with a cytidine deaminase to detect and optionally map 5mC in a DNA. Optionally, a second portion can be reacted with glucosyltransferase followed by reaction with a cytidine deaminase to detect and optionally map 5hmC in a DNA.

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Patent Owner(s)

Patent OwnerAddress
NEW ENGLAND BIOLABS INC240 COUNTY ROAD IPSWICH MA 01938

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davis, Theodore B Boxford, US 17 133
Ettwiller, Laurence Beverly, US 16 77
Guan, Shengxi Stoneham, US 46 253
Saleh, Lana Hamilton, US 10 116
Sun, Zhiyi Gloucester, US 15 109
Vaisvila, Romualdas Ipswich, US 20 238

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